There are many case reports and some clinical trials that demonstrate chiropractic benefit with "Type O" or non-musculo-skeletal disorders.

Infantile colic and ear infections have been demonstrated to respond favorably compared to standard medical care.

Research has shown that many people undergoing chiropractic care for musculo-skeletal complaints also report other organ system benefits, with as many as 25-30% reported improvements in breathing problems, digestion, and circulation among others.